{"id":165,"date":"2025-04-09T03:27:00","date_gmt":"2025-04-09T03:27:00","guid":{"rendered":"https:\/\/tomfarandasfolly.com\/?p=165"},"modified":"2025-09-27T20:56:55","modified_gmt":"2025-09-27T20:56:55","slug":"smithsonian-left-handedness-linked-to-rare-genetic-variants-im-mostly-a-leftie","status":"publish","type":"post","link":"https:\/\/tomfarandasfolly.com\/?p=165","title":{"rendered":"Smithsonian &#8211; Left handedness linked to rare genetic variants (I&#8217;m &#8211; mostly &#8211; a leftie)"},"content":{"rendered":"<p>I am left handed with two variations &#8211; I bat rightie and my dominant kicking leg is right. And now I&#39;m even more special!<\/p>\n<p><a href=\"https:\/\/getpocket.com\/explore\/item\/why-are-some-people-left-handed-scientists-identify-rare-genetic-variants-that-may-be-linked-to-the?utm_source=firefox-newtab-en-us\">Rare Genetic Variants That May Be Linked to Left-Handedness<\/a><\/p>\n<p class=\"body\">Around 90 percent of people are right-handed, and 10 percent are left-handed. Which hand people rely on is a result of brain asymmetry\u2014when it comes to hand control, left-handed people have dominant right sides of their brain, while righties have dominant left sides, per the study.<\/p>\n<p class=\"body\">This asymmetry develops in the womb and manifests in different ways. \u201cFor example, most people have left-hemisphere dominance for language, and right-hemisphere dominance for tasks that require directing visual attention to a location in space,\u201d <a href=\"https:\/\/www.mpi.nl\/people\/francks-clyde\">Clyde Francks<\/a>, a co-author of the new study and a geneticist at the Max Planck Institute for Psycholinguistics in the Netherlands, tells <a href=\"https:\/\/www.reuters.com\/science\/gene-involved-cell-shape-offers-clues-left-handedness-2024-04-02\/\">Reuters<\/a>\u2019 Will Dunham.<\/p>\n<p class=\"body\">********************************<\/p>\n<p class=\"body\">The team examined data from the UK Biobank\u2014a massive biomedical database\u2014analyzing genes from 38,043 lefties and 313,271 righties. The TUBB4B variants were present in fewer than 1 percent of people, but they were 2.7 times more likely to appear in lefties than in righties.<\/p>\n<p class=\"body\">\u201cThis is an important and significant study\u201d that supports the role of tubulins in determining the asymmetry between the brain\u2019s hemispheres, <a href=\"https:\/\/loop.frontiersin.org\/people\/43316\/bio\">Sebastian Ocklenburg<\/a>, a neuroscientist at the Medical School Hamburg in Germany who did not contribute to the findings, tells <a href=\"https:\/\/www.nature.com\/articles\/d41586-024-00977-x#ref-CR1\"><em>Nature News<\/em><\/a>\u2019 Sumeet Kulkarni.<\/p>\n<p class=\"body\">The findings provide further evidence that microtubules are connected to whether a person prefers to use their right or left hand, the study authors write. And the researchers offer a possible reason why: Microtubules support the structure and movement of cilia, hair-like organelles sticking out of cells that can direct the flow of surrounding fluid. An uneven fluid flow, they suggest in the paper, might play a role in the development of brain asymmetry.<\/p>\n<p class=\"body\">While rare genetic variants only affect a small number of people, they \u201ccan give clues to developmental mechanisms of brain asymmetry in everyone,\u201d Francks tells <em>Nature News<\/em>.<\/p>\n<p class=\"body\">Still, handedness could come down to chance a lot of the time. \u201cWe think that most instances of left-handedness occur simply due to random variation during development of the embryonic brain, without specific genetic or environmental influences,\u201d Francks says to Reuters.<\/p>\n<p>&#0160;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>I am left handed with two variations &#8211; I bat rightie and my dominant kicking leg is right. And now I&#39;m even more special! Rare Genetic Variants That May Be Linked to Left-Handedness Around 90 percent of people are right-handed, and 10 percent are left-handed. Which hand people rely on is a result of brain [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-165","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/tomfarandasfolly.com\/index.php?rest_route=\/wp\/v2\/posts\/165","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/tomfarandasfolly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/tomfarandasfolly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/tomfarandasfolly.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/tomfarandasfolly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=165"}],"version-history":[{"count":1,"href":"https:\/\/tomfarandasfolly.com\/index.php?rest_route=\/wp\/v2\/posts\/165\/revisions"}],"predecessor-version":[{"id":7010,"href":"https:\/\/tomfarandasfolly.com\/index.php?rest_route=\/wp\/v2\/posts\/165\/revisions\/7010"}],"wp:attachment":[{"href":"https:\/\/tomfarandasfolly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=165"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/tomfarandasfolly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=165"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/tomfarandasfolly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=165"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}